C/EBP-beta (S229/182) polyclonal antibody

P17676

C/EBP beta is a member of the C/EBP transcription factor family. The C/EBP beta gene encodes several isoforms, which have truncated transcription activation domains by the alternative translational initiation at multipe AUG start sites. Initiation of translation at the in-frame AUGs forms four C/EBP beta isoforms. C/EBP beta is also known as interleukin 6-dependent DNA-binding protein (IL6DBP), liver activator protein(LAP) or liver-enriched transcriptional activator protein transcription factor 5 (TCF5). C/EBP beta contributes to the regulation of the acute phase response in hepatocytes. Stat3 has an important function in IL-6-mediated transcription of the C/EBP beta gene that has direct implication for acute phase response in liver cells.The 35 kDa C/EBP beta form requires phosphorylation for its DNA binding ability, and increased binding of C/EBP beta isoforms during acute-phase reaction occurs through its upregulation and structural modification.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

C/EBP-beta (S229/182) pAb detects endogenous levels of total C/EBP-beta protein.

Immunohistochemistry (IHC) analyzes of C/EBP-beta (S229/182) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

For research use only, not for use in diagnostic procedure.

Synthetic peptide, corresponding to amino acids 200-250 of Human C/EBP-beta.