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DNAM-1 (Y325) polyclonal antibody

DNAM-1 (Y325) polyclonal antibody

ArtNr	AP0431-50
Hersteller	Bioworld Technology, Inc
Menge	50ul
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, DNAM1
Similar products	DNAM-1
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Swiss-Prot	Q15762
Application all	WB: 1:500ca.1:1000
Background	DNAM 1 is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes. This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.
Product	1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	DNAM 1 (Y325) pAb detects endogenous levels of DNAM 1 protein.
WB	Western blot (WB) analysis of DNAM-1 (Y325) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate
BiowMW	ca. 38 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, DNAM1
Immunogen	Synthetic peptide, corresponding to amino acids 293-342 of Human DNAM-1.

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