ZNF262 (H837) polyclonal antibody

Q5VZL5

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF262, also known as ZMYM4, is a 1, 548 amino acid protein that contains 9 MYM-type zinc fingers. Four ZNF262 isoforms are expressed due to alternative splicing events, and are found in heart, skeletal muscle, kidney and liver. Upon DNA damage, ZNF262 may be phosphorylated by ATM or ATR. The mRNA encoding ZNF262 contains a CDIR motif (cell death inhibiting RNA) which binds to HNRPD/AUF1 and HSPB1/HSP27 and can inhibit FN-gamma induced apoptosis. The gene encoding ZNF262 maps to chromosome 1, which spans about 260 million base pairs and comprises nearly 8% of the human genome.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

ZNF262 (H837) pAb detects endogenous levels of ZNF262 protein.

ca. 173 kDa

CDIR, Cell death inhibiting RNA, MYM, Zinc finger protein 262, Zinc finger, MYM type 4, ZMYM4, ZNF198L3,