ArtNr |
BS9170-100 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, IHC |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CDIR, Cell death inhibiting RNA, MYM, Zinc finger protein 262, Zinc finger, MYM type 4, ZMYM4, ZNF198L3, |
Similar products |
ZNF262 |
Lieferbar |
|
Swiss-Prot |
Q5VZL5 |
Application all |
WB: 1:500ca.1:1000
IHC: 1:50ca.1:200 |
Background |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF262, also known as ZMYM4, is a 1, 548 amino acid protein that contains 9 MYM-type zinc fingers. Four ZNF262 isoforms are expressed due to alternative splicing events, and are found in heart, skeletal muscle, kidney and liver. Upon DNA damage, ZNF262 may be phosphorylated by ATM or ATR. The mRNA encoding ZNF262 contains a CDIR motif (cell death inhibiting RNA) which binds to HNRPD/AUF1 and HSPB1/HSP27 and can inhibit FN-gamma induced apoptosis. The gene encoding ZNF262 maps to chromosome 1, which spans about 260 million base pairs and comprises nearly 8% of the human genome. |
Product |
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
ZNF262 (H837) pAb detects endogenous levels of ZNF262 protein. |
IHC |
Immunohistochemistry (IHC) analyzes of ZNF262 (H837) pAb in paraffin-embedded human breast cancer tissue. |
BiowMW |
ca. 173 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
CDIR, Cell death inhibiting RNA, MYM, Zinc finger protein 262, Zinc finger, MYM type 4, ZMYM4, ZNF198L3, |
Immunogen |
Synthetic peptide, corresponding to amino acids 804-856 of Human ZNF262. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.