ArtNr |
BS71724-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
DOC1, ST19, DORC1, doc-1, p12DOC-1, |
Lieferbar |
|
Buffer composition |
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Background |
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Application info |
WB 1:200 - 1:1000 |
Swiss-Prot |
O14519 |
Purification and Purity |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
Storage and Stability |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Specificity |
CDK2AP1 polyclonal antibody detects endogenous levels of CDK2AP1 protein. |
BiowMW |
Predicted band size: 13 kDa Observed band size: Refer to Figures |
Note |
For research use only, not for use in diagnostic procedure. |
Alternative Name |
DOC1, ST19, DORC1, doc-1, p12DOC-1, |
Immunogen |
A synthetic peptide of human CDK2AP1 |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.