TNF-beta / LTA polyclonal antibody

P01374

Tumor necrosis factor b (TNFb), also known as lymphotoxin, is a pleiotropic cytokine. TNFa, also known as cachectin, is a smaller cytokine that binds to the same receptors, producing a vast array of effects similar to those of TNFb. TNFb and TNFa share 30% amino acid homology and have similar biological activities. TNFb is produced by activated lymphocytes, including CD4(+) T helper cell type 1 lymphocytes, CD8(+) lymphocytes and certain B lymphoblastoid cell lines. TNFa is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFa and TNFb can modulate many immune and inflammatory functions, while having the ability to inhibit tumor growth.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

LTA pAb detects endogenous levels of LTA protein.

ca. 22 kDa

Lymphotoxin-alpha, LT-alpha, TNF-beta, Lymphotoxin alpha, LTalpha, TNFbeta, Tumor necrosis factor ligand superfamily member 1, LTA, TNFB, TNFSF1