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Rabbit polyclonal antibody to Human Caspase 6 (CASP-6,Mch-2), Affinity Purified

Rabbit polyclonal antibody to Human Caspase 6 (CASP-6,Mch-2), Affinity Purified

ArtNr	R-1705-100
Hersteller	Biosensis
Menge	100ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Gastric Cancer Uterine, Ovarian & Cervical Cancer
Typ	Antibody Polyclonal
Applikationen	WB
Specific against	Human
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CASP6, Apoptotic protease Mch-2, caspase6, CASP-6, Mch2
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Sub category	Alzheimer's / Parkinson's-Apoptosis-Cancer
products_extra_fields_value	Caspases play several key roles in cellular growth and development, extracellular matrix remodeling, wound healing, homeostasis, and are implicated in a wide range of diseases from auto immune dysfunction to cancer metastases as well. A Caspases are Cysteine ASpartate Proteases which form a family of metalloproteinases of which there are more than a dozen members. Caspases are all normally expressed in cells as inactive precursor zymogens that then get activated via proteolytic cleavage to form active enzyme complexes. A Activation can occur by several means and programmed cell death, or apoptosis, is among the most studied, but there are several others since caspases are involved in so many critical and disease states. A Among the 14 or so members, Caspase-6 is particularly interesting because it has been implicated in playing a role in some neurodegenerative diseases including Alzheimera€s and Huntingtona€s disease. A Caspase-6 has been shown to cut amyloid precursor protein (APP), at position 720 leading to the toxic fragment Jcasp, which is one of the fragments found in amyloid plaques which are believed to be an indicator of the disease, and in Huntingtona€s disease, the specific amino acid sequence (IVLD586G) is recognized by Caspase-6 A on the Huntington protein (htt) in mice with Huntingtona€s disease. The proteolytic cleavage of htt liberates toxic fragments containing the expanded polyglutamine tract that are neurotoxic and that stimulates additional proteolytic activity leading to apoptosis and neurodegeneration. Mutation of the Caspase-6 site in mice model with Alzheimera€s and Huntingtona€s disease provides protection from the neural dysfunction, suggesting a causal relationship between Caspase-6 cleavage and neurodegeneration. Biosensis is pleased to offer a rabbit polyclonal antibody to human Caspase 6 that reacts in paraffin embedded immunohistochemistry and western blotting for your continued research into Caspase 6 and its potential roles in both normal and pathological conditions.
products_quantity	2
storage	Store dry, unopened vial at -20C for one year, after reconstitution aliquot in to single use sizes and store at 4C for up to one month, store aliquots frozen at -70C for up to six months, protected from light and prevent multiple freeze thaw cycles.
purityisotype	Affinity purified polyclonal IgG
formulation	Freeze-dried powder from liquid containing PBS, 5 mg BSA, 0.05mg Thimerosal and 0.05mg sodium azide.
immunogen	A synthetic peptide corresponding to an amino acid sequence at the N-terminal of human Caspase 6 comprising amino acids 24-44 of human Caspase 6
crossreactivity	Potential reactivity to mouse Caspase 6 based upon sequence homology but as yet untested.
conality	Rabbit
specificity	Human Caspase 6 protein, no reactivity to other human caspases
reconstitution	Reconstitute vial in 0.2 mL of sterile distilled water. This will produce a final concentration of 500ug/mL of antibody.

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