Recombinant Mouse Merlin (Nf2), partial

Moesin-ezrin-radixin-like protein (Neurofibromin-2) (Schwannomin) (Nf-2)

E.coli

MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEF NCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKD TVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENA EEELVQEITQHLFFLQVKKQILDEKVYCPPEASVL LASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVIN LYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI AQDLEMYGVNYFTIRNKKGTELLLGVDALGLHIYD PENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKI DVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADS LEVQQ

N-terminal 6xHis-Trx-tagged

>85% as determined by SDS-PAGE.

Not tested

Ice packs

1 year

Probable regulator of the Hippo/SWH signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.