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Recombinant Mouse Perforin-1 (Prf1)

Recombinant Mouse Perforin-1 (Prf1)

ArtNr	BM-RPC25638-1mg
Hersteller	Biomatik
Menge	1mg
Kategorie	Neuroscience Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	Mouse
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Cytolysin Lymphocyte pore-forming protein Short name: PFP
Similar products	Cytolysin Lymphocyte pore-forming protein Short name: PFP
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Gene Name	Prf1
Alternative Names	Cytolysin Lymphocyte pore-forming protein Short name: PFP
Uniprot	P10820
Source	E.coli
Expression Region	21-554aa
AA Sequence	PCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRS GSFPVNTQRFLRPDRTCTLCKNSLMRDATQRLPVA ITHWRPHSSHCQRNVAAAKVHSTEGVAREAAANIN NDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEK TYQDQYNFNSDTVECRMYSFRLVQKPPLHLDFKKA LRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGG RISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSI GAQASVSSEYKACEEKKKQHKMATSFHQTYRERHV EVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNP GLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSR ARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQD CCPRQRGLAHLVVSNFRAEHLWGDYTTATDAYLKV FFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGG PLRVQVWDADYGWDDDLLGSCDRSPHSGFHEVTCE LNHGRVKFSYHAKCLPHLTGGTCLEYAPQGLLGDP PGNRSGAVW
Sequence Info	Full Length of Mature Protein
Tag Info	N-terminal 6xHis-tagged
Theoretical MW	63.9 kDa
Purity	>85% as determined by SDS-PAGE.
Storage Buffer	Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Endotoxin Level	Not tested
Biological Activity	Not tested
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Function	Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
Subcellular location	Cytoplasmic granule lumen, Secreted, Cell membrane, Multi-pass membrane protein, Endosome lumen
Protein Families	Complement C6/C7/C8/C9 family
Tissue Specificity	Detected in cytotoxic T-lymphocytes and natural killer cells.

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Menge: 1mg

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Lieferung vsl. bis 27.12.2024

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