ArtNr |
BM-RPC25638-1mg |
Hersteller |
Biomatik
|
Menge |
1mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Mouse (Murine, Mus musculus) |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Cytolysin Lymphocyte pore-forming protein Short name: PFP |
Similar products |
Cytolysin Lymphocyte pore-forming protein Short name: PFP |
Lieferbar |
|
Gene Name |
Prf1 |
Alternative Names |
Cytolysin Lymphocyte pore-forming protein Short name: PFP |
Uniprot |
P10820 |
Source |
E.coli |
Expression Region |
21-554aa |
AA Sequence |
PCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRS GSFPVNTQRFLRPDRTCTLCKNSLMRDATQRLPVA ITHWRPHSSHCQRNVAAAKVHSTEGVAREAAANIN NDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEK TYQDQYNFNSDTVECRMYSFRLVQKPPLHLDFKKA LRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGG RISVLTALRTCQLTLNGLTADEVGDCLNVEAQVSI GAQASVSSEYKACEEKKKQHKMATSFHQTYRERHV EVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNP GLVDYSLEPLHTLLEEQNPKREALRQAISHYIMSR ARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQD CCPRQRGLAHLVVSNFRAEHLWGDYTTATDAYLKV FFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGG PLRVQVWDADYGWDDDLLGSCDRSPHSGFHEVTCE LNHGRVKFSYHAKCLPHLTGGTCLEYAPQGLLGDP PGNRSGAVW |
Sequence Info |
Full Length of Mature Protein |
Tag Info |
N-terminal 6xHis-tagged |
Theoretical MW |
63.9 kDa |
Purity |
>85% as determined by SDS-PAGE. |
Storage Buffer |
Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Endotoxin Level |
Not tested |
Biological Activity |
Not tested |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. |
Function |
Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. |
Subcellular location |
Cytoplasmic granule lumen, Secreted, Cell membrane, Multi-pass membrane protein, Endosome lumen |
Protein Families |
Complement C6/C7/C8/C9 family |
Tissue Specificity |
Detected in cytotoxic T-lymphocytes and natural killer cells. |
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