ArtNr |
BM-RPC26894-50ug |
Hersteller |
Biomatik
|
Menge |
50ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Human |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
Interleukin-4, IL-4, B-Cell Stimulatory Factor 1, BSF-1, Binetrakin, Lymphocyte Stimulatory Factor 1, Pitrakinra, IL4 |
Similar products |
IL-4, IL4, Interleukin-4, BSF-1, Binetrakin, Pitrakinra, B-Cell Stimulatory Factor 1, Lymphocyte Stimulatory Factor 1 |
Lieferbar |
|
Gene Name |
IL4 |
Alternative Names |
Interleukin-4, IL-4, B-Cell Stimulatory Factor 1, BSF-1, Binetrakin, Lymphocyte Stimulatory Factor 1, Pitrakinra, IL4 |
Uniprot |
P05112 |
Source |
Mammalian cell |
Expression Region |
25-153aa |
AA Sequence |
HKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAA SKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATA QQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEAN QSTLENFLERLKTIMREKYSKCSS |
Sequence Info |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Theoretical MW |
14.97 kDa |
Purity |
>95% as determined by SDS-PAGE. |
Storage Buffer |
Lyophilized from a 0.2 um filtered 20 mM PB, 150 mM NaCl, pH 7.4 |
Endotoxin Level |
Less than 1.0 EU/ug as determined by LAL method. |
Biological Activity |
The ED50 as determined in a cell proliferation assay using TF?1 human erythroleukemic cells is less than 0.2 ng/ml. |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response. |
Function |
Participates in at least several B-cell activation processes as well as of other cell types |
Involvement in disease |
Ischemic stroke (ISCHSTR) |
Subcellular location |
Secreted |
Protein Families |
IL-4/IL-13 family |
Paythway |
Jak-STATsignalingpathway |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.