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Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15) (Active)

Recombinant Human Tumor necrosis factor ligand superfamily member 15 protein (TNFSF15) (Active)

ArtNr	BM-RPC26715-100ug
Hersteller	Biomatik
Menge	100ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Typ	Proteins Recombinant
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TNF ligand-related molecule 1,
Similar products	TNF ligand-related molecule 1
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Gene Name	TNFSF15, TL1, VEGI
Alternative Names	TNF ligand-related molecule 1,
Uniprot	O95150
Source	E.coli
Expression Region	72-251aa
AA Sequence	LKGQEFAPSH QQVYAPLRAD GDKPRAHLTV VR QTPTQHFK NQFPALHWEH ELGLAFTKNR MNYT NKFLLI PESGDYFIYS QVTFRGMTSE CSEIRQ AGRP NKPDSITVVI TKVTDSYPEP TQLLMGTK SV CEVGSNWFQP IYLGAMFSLQ EGDKLMVNVS DISLVDYTKE DKTFFGAFLL
Sequence Info	Partial
Tag Info	Tag-Free
Theoretical MW	20.5 kDa
Purity	>97% as determined by SDS-PAGE and HPLC.
Storage Buffer	Lyophilized from a 0.2 um filtered PBS, pH 7.4, with 0.02% Tween-20
Endotoxin Level	Less than 1.0 EU/ug as determined by LAL method.
Biological Activity	The ED50 as determined by its ability to induce apoptosis using human TF-1 cells is less than 20 ng/ml, corresponding to a specific activity of ? 5.0 x 104 IU/mg.
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis. {ECO:0000269\|PubMed:10597252, ECO:0000269\|PubMed:11911831, ECO:0000269\|PubMed:11923219, ECO:0000269\|PubMed:9872942}.
Function	Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Subcellular location	Membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted
Protein Families	Tumor necrosis factor family
Tissue Specificity	Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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