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Recombinant Human Prolactin receptor (PRLR)

Recombinant Human Prolactin receptor (PRLR)

ArtNr	BM-RPC20748-100ug
Hersteller	Biomatik
Menge	100ug
Kategorie	Oncology By Cell Type Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	Human
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
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Gene Name	PRLR
Uniprot	P16471
Source	in vitro E.coli expression system
Expression Region	25-622aa
AA Sequence	QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTN YSLTYHREGETLMHECPDYITGGPNSCHFGKQYTS MWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDP PLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWF TLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPG QKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMND TTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFP PVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPT SDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMK PTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTF YDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAG GSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPA GAPATLLNEAGKDALKSSQTIKSREEGKATQQREV ESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHK VNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKV SGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLE QNQAEKALANFTATSSKCRLQLGGLDYLDPACFTH SFH
Sequence Info	Full Length of Mature Protein
Tag Info	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Theoretical MW	71.9 kDa
Purity	>85% as determined by SDS-PAGE.
Storage Buffer	Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Endotoxin Level	Not tested
Biological Activity	Not tested
Shipping Condition	Ice packs
Storage	Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles.
Expiry Date	1 year
Restriction	For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals.
Relevance	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Function	This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Involvement in disease	Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL)
Subcellular location	Membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 7: Secreted
Protein Families	Type I cytokine receptor family, Type 1 subfamily
Tissue Specificity	Expressed in breast, placenta, kidney, liver and pancreas.
Paythway	Jak-STATsignalingpathway

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Menge: 100ug

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