ArtNr |
BM-RPC20748-100ug |
Hersteller |
Biomatik
|
Menge |
100ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Human |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Gene Name |
PRLR |
Uniprot |
P16471 |
Source |
in vitro E.coli expression system |
Expression Region |
25-622aa |
AA Sequence |
QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTN YSLTYHREGETLMHECPDYITGGPNSCHFGKQYTS MWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDP PLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWF TLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPG QKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMND TTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFP PVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPT SDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMK PTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTF YDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAG GSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPA GAPATLLNEAGKDALKSSQTIKSREEGKATQQREV ESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHK VNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKV SGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLE QNQAEKALANFTATSSKCRLQLGGLDYLDPACFTH SFH |
Sequence Info |
Full Length of Mature Protein |
Tag Info |
N-terminal 10xHis-tagged and C-terminal Myc-tagged |
Theoretical MW |
71.9 kDa |
Purity |
>85% as determined by SDS-PAGE. |
Storage Buffer |
Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Endotoxin Level |
Not tested |
Biological Activity |
Not tested |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. |
Function |
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. |
Involvement in disease |
Multiple fibroadenomas of the breast (MFAB); Hyperprolactinemia (HPRL) |
Subcellular location |
Membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 7: Secreted |
Protein Families |
Type I cytokine receptor family, Type 1 subfamily |
Tissue Specificity |
Expressed in breast, placenta, kidney, liver and pancreas. |
Paythway |
Jak-STATsignalingpathway |
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