Hersteller |
Biomatik
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
Equine |
Menge |
100ug |
ArtNr |
BM-RPC26545-100ug |
Targets |
CD121a;;IL6R |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Alias |
Interleukin-1 receptor antagonist protein Short name: IL-1RN Short name: IL-1ra Short name: IRAP Alternative name(s): IL1 inhibitor |
Gene Name |
IL1RN |
Alternative Names |
Interleukin-1 receptor antagonist protein Short name: IL-1RN Short name: IL-1ra Short name: IRAP Alternative name(s): IL1 inhibitor |
Uniprot |
O18999 |
Source |
E.coli |
Expression Region |
26-177aa |
AA Sequence |
HPLGKRPCKM QAFRIWDVNQ KTFYMRNNQL VA GYLQESNT KLQEKIDVVP IEPDALFLGL HGRK LCLACV KSGDEIRFQL EAVNITDLSK NKEENK RFTF IRSNSGPTTS FESAACPGWF LCTAQEAD RP VSLTNKPKES FMVTKFYLQE DQ |
Sequence Info |
Full Length of Mature Protein |
Tag Info |
Tag-Free |
Theoretical MW |
17.4 kDa |
Purity |
>95% as determined by SDS-PAGE and HPLC. |
Storage Buffer |
Lyophilized from a 0.2 um filtered PBS, pH 7.4 |
Endotoxin Level |
Less than 1.0 EU/ug as determined by LAL method. |
Biological Activity |
The ED50 as determined by inhibiting IL-1alpha- dependent proliferation of murine D10S cells is less than 3.0 ug/ml, corresponding to a specific activity of ? 333 IU/mg in the presence of 50 pg/ml rHuIL-1alpha. |
Shipping Condition |
Ice packs |
Storage |
Short term: -20CC; Long term: -80CC. Minimize freeze and thaw cycles. |
Expiry Date |
1 year |
Restriction |
For Research Use Only. Not for use in diagnostic procedures, drug use, or for administration to humans or animals. |
Relevance |
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. |
Function |
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. |
Subcellular location |
Secreted |
Protein Families |
IL-1 family |
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