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Anti-Mouse NK1.1 (CD161) Purified Size 100 ug

ArtNr 83712-20-100
Hersteller BioGems
Menge 100 ug
Kategorie
Typ Antibody
Format Purified
Applikationen FC, IP
Clon PK136
Specific against Mouse
Host Mouse
Isotype IgG2a kappa
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Lieferbar
Description
The PK136 monoclonal antibody is specific for the mouse NK1.1, a receptor from the killer cell lectin-like receptor (KLR) family. Nk1.1 is an antigen encoded by the Klrb1c/NKR-P1C gene expressed by the natural killer cells of some selected strains of mice (C57BL, FVB/N, NZB) and encoded by the Klrb1b/NKR-P1B gene expressed on Swiss NIH and SJL mice. Pk136 binds to an epitope common to NKR-P1B and NKR-P1C.

The Klrb1 is a family of type II transmembrane C-type lectin receptors. Klrb1c activates the NK-cell cytotoxicity, while Klrb1b inhibits it.

PK136 is useful in defining the NK cells and the rare population of NK-T lymphocytes and specific cultured monocytes.

Research Interest
Innate Immunity
Preperation
The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation
Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References

Koo, G. C., & PEPPARD, J. R. (1984). Establishment of monoclonal anti-Nk-1.1 antibody. Hybridoma, 3(3), 301-303.

Carlyle, J. R., Martin, A., Mehra, A., Attisano, L., Tsui, F. W., & Zuniga-Pflücker, J. C. (1999). Mouse NKR-P1B, a novel NK1. 1 antigen with inhibitory function. The Journal of Immunology, 162(10), 5917-5923.

Karlhofer, F. M., & Yokoyama, W. M. (1991). Stimulation of murine natural killer (NK) cells by a monoclonal antibody specific for the NK1. 1 antigen. IL-2-activated NK cells possess additional specific stimulation pathways. The Journal of Immunology, 146(10), 3662-3673.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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