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Anti-Mouse CD86 (B7-2) PE-Cyanine7

Anti-Mouse CD86 (B7-2) PE-Cyanine7

ArtNr	08912-77-25
Hersteller	BioGems
Menge	25 ug
Kategorie	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Immunohistochemistry Primary Antibodies
Typ	Antibody
Format	PE-Cy7
Applikationen	FC, IHC
Clon	GL-1 (GL1)
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2a Kappa
Konjugat/Tag	PE, Cy7
Citations	Hathcock, K. S., Laszlo, G., Dickler, H. B., Bradshaw, J., Linsley, P., & Hodes, R. J. (1993). Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science, 262(5135), 905-907. Inaba, K., Witmer-Pack, M., Inaba, M., Hathcock, K. S., Sakuta, H., Azuma, M., ... & Steinman, R. M. (1994). The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. The Journal of experimental medicine, 180(5), 1849-1860. Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P., & Hodes, R. J. (1994). Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. The Journal of experimental medicine, 180(2), 631-640.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Description	The GL-1 monoclonal antibody reacts specifically with the mouse B7-2 (also known as CD86), a costimulatory molecule expressed by B and T lymphocytes, macrophages (thioglycollate-induced from peritoneum), astrocytes and dendritic cells. The memory CD4+ T lymphocytes express CD86 (as mRNA and protein). CD86, and the B7-1 (CD 80) molecule, are ligands for CD152 and CD28, and influence the costimulatory interactions between lymphocytes B and T. B7-2 is also involved in the mouse natural killer cell-mediated cytotoxicity. The GL-1 antibody blocks the mixed lymphocyte reaction (MLR) and inhibits the T-cells stimulation by antigen-presenting cells. Mixtures of anti-B7-1 antibody and GL-1 were reported to inhibit the interaction between CD125 and its ligand with the in vivo priming of cytotoxic T lymphocytes.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µ g of the protein.
Research Interest	Innate Immunity

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