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Eya4 Peptide - middle region (AAP39975)

Hersteller AVIVA Systems Biology
Kategorie
Typ Peptides
Specific against Human, Mouse
Format Lyophilized powder
Applikationen WB
Menge 100ug
ArtNr AAP39975
eClass 6.1 34160400
eClass 9.0 32160409
Lieferbar
Alias B130023L16Rik
Description
This is a synthetic peptide designed for use in combination with anti-Eya4 Antibody (ARP39975_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Gene symbol
Eya4
Protein size
616
Molecular weight
67kDa
Product format
Lyophilized powder
Gene id
14051
Reconstitution and storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20C. Avoid repeat freeze-thaw cycles.
Partner proteins
Eya4, Six1, Six2
Description of target
Eya4 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Eya4 promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. It may be involved in development of the eye.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100ug
Lieferbar: In stock
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