BIN2 ELISA Kit (Human) (OKCD01058)

bridging integrator 2

51411

Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.1 Publication < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.9"Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."_x005F_x000D_ Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T._x005F_x000D_ PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]Cited for: X-RAY CRYSTALLOGRAPHY (2.53 ANGSTROMS) OF 1-238, FUNCTION, DOMAIN, SUBUNIT, INTERACTION WITH ARHGEF6; ARHGEF7; SH3GL1; SH3GL2; SH3GL3, IDENTIFICATION IN A COMPLEX WITH GIT2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF PHE-13; PHE-21; VAL-81 AND SER-214.

< 0.112 ng/mL