Hersteller |
AVIVA Systems Biology
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human |
Isotype |
Ig |
Format |
Liquid. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
Applikationen |
WB |
Menge |
400 ul |
Host |
Rabbit |
ArtNr |
OAAB18264 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Alias |
ERBB2, HER2, MLN19, NEU, NGL, Receptor tyrosine-protein kinase erbB-2, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Receptor tyrosine-protein kinase erbB-2, Pr |
Gene symbol |
ERBB2 |
Molecular weight |
138 kDa |
Product format |
Liquid. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
Gene id |
2064 |
Reconstitution and storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Description of target |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth. |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
Clonality |
Polyclonal |
Immunogen |
This ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1222 of human ERBB2. |
Drywet |
Wet Ice |
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