ArtNr |
OAAI00474 |
Hersteller |
AVIVA Systems Biology
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
S6K, PS6K, S6K1, STK14A, p70-S6K, p70 S6KA, p70-alpha, S6K-beta-1, p70(S6K)-alpha |
Similar products |
p70-S6K, STK14A, PS6K, S6K, S6K1, p70(S6K)-alpha, p70-alpha, S6K-beta-1, p70 S6KA |
Lieferbar |
|
Gene symbol |
RPS6KB1 |
Molecular weight |
70 kDa |
Gene id |
6198 |
Reconstitution and storage |
The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C to 8C for three month without detectable loss of activity. Avoid repeated freezing thawing cycles. |
Description of target |
S6 kinase, or p70 S6 Kinase, a mitogen activated Ser/Thr protein kinase, is required for cell growth and G1 cell cycle progression. P70 S6 Kinase and single 4E-BP are phosphorylated via the insulin and target of rapamycin (TOR) signaling pathway which is independent of PI3K and AKT activity. On the other hand, the oncogenic transformation by P3k and Akt is dependent on targets that control translation: transforming activity , which is correlated with phosphorylation and activation of S6K and eliminated by the mTOR inhibitor rapamycin. S6K phosphorylates the S6 protein of the 40S ribosomal subunit. |
Purification |
The Rabbit IgG is purified by Epitope Affinity Purification. |
Clonality |
Polyclonal |
Immunogen |
A synthetic peptide corresponding to the C-terminus of Human p70S6K protein. This sequence is identical within Human, Rat, Mouse, bovine, chicken and dog. |
Drywet |
Wet Ice |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.