ArtNr |
ARP40675_P050 |
Hersteller |
AVIVA Systems Biology
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Lyophilized powder |
Applikationen |
WB |
Specific against |
Human, Mouse, Rat, Porcine, Rabbit, Guinea Pig, Bovine, Canine, Equine |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
CPSF30, NAR, NEB1 |
Similar products |
CPSF4 |
Lieferbar |
|
Gene symbol |
CPSF4 |
Protein name |
Cleavage and polyadenylation specificity factor subunit 4 |
Protein size |
216 |
Molecular weight |
24kDa |
Subunit |
4 |
Product format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Gene id |
10898 |
Reconstitution and storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Partner proteins |
FIP1L1. RBBP6. MEOX2. CLK2. NPM1. MDC1. ECT2. UBC. CSTF2T. RRAGA. CDC73. SLC12A9. MARK3. |
Description of target |
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. |
Homology |
Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100% |
Purification |
Affinity Purified |
Clonality |
Polyclonal |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human CPSF4 |
Drywet |
Wet Ice |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.