Anti-NPHS1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O60500

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

NPHS1

Rabbit polyclonal against NPHS1

Cell Membrane
Single-Pass Type I Membrane Protein
Predominantly Located At Podocyte Slit Diaphragm Between Podocyte Foot Processes
Also Associated With Podocyte Apical Plasma Membrane

WB 1:500-1:2000

Nephrin
Renal Glomerulus-Specific Cell Adhesion Receptor

NPHN_HUMAN