Anti-CD40 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P25942

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

CD40

Synthetic peptide of human CD40

B-cells and in primary carcinomas.

Calculated: 22kDa/30kDa.

Anti-Tumor Necrosis Factor Receptor Superfamily Member 5 antibody
Anti-B-Cell Surface Antigen Cd40 antibody
Anti-Bp50 antibody
Anti-Cd40l Receptor antibody
Anti-Cdw40 antibody
Anti-Cd Antigen Cd40 antibody
Anti-CD40 TNFRSF5 antibody

FOR RESEARCH USE ONLY (RUO).