Rabbit anti-Human Tau mAb(DET）

Tau is a microtubule-associated protein expressed primarily in neurons.? Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane.? Abnormal Tau phosphorylation?may result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer's disease and other neurodegenerative diseases.? Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death.? There are multiple forms of Tau--this?441 amino acid isoform is known as "2N4R, " "Isoform Tau-F, "?"Tau-4" or "Tau 441" and is referenced in UniProt as P10636-8.? This recombinant protein is untagged.

Recombinant Human Tau Protein
Gln88-Arg230
Accession #P10636

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.