Background |
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
Manufacturers Research Area |
AMPK Signaling Pathway, Apoptosis, Autophagy, Cancer, Cell Biology & Developmental Biology, Cell Cycle, Cell Cycle_Cell cycle inhibitors, Endocrine & Metabolism, Epigenetics & Nuclear Signaling, Insulin Receptor Signaling Pathway, Kinase, Kinase_Serine/threonine kinases, mTOR Signaling Pathway, PI3K-Akt Signaling Pathway, PI3K-Akt Signaling Pathway_Regulator of mTOR complex function, Protein phosphorylation, Signal Transduction, Translation Control, Translational Control_Regulation of eIF4 and p70 S6 Kinase, Tumor suppressors, Tumor suppressors_p53 pathway, Warburg Effect, |