Alias |
FLJ39654,FRTS4,Hepatic nuclear factor 4 alpha,Hepatocyte nuclear factor 4 alpha,Hepatocyte nuclear factor 4,Hepatocyte nuclear factor 4-alpha,HNF 4 alpha,HNF 4,HNF-4-alpha,HNF4,HNF4A,HNF4A,HNF4a7,HNF4a8,HNF4a9,Hnf4alpha,HNF4alpha10/11/12,MODY 1,MODY,MODY1,NR2A1,NR2A21,Nuclear receptor subfamily 2 group A member 1,OTTHUMP00000031060,OTTHUMP00000031062,TCF 14,TCF,TCF-14,TCF14,Tcf4,Transcription factor 14,hepatic nuclear factor,Transcription factor 14,Transcription factor HNF 4,Transcription factor HNF-4,Transcription factor HNF4 |
Background |
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. |