ArtNr |
RD85741A-60uL |
Hersteller |
Reddot Biotech
|
Menge |
60 uL |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
WB, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
UBB,Polyubiquitin-B,UBC,Polyubiquitin-C,RPS27A,UBA80,UBCEP1,Ubiquitin-40S ribosomal protein S27a,Ubiquitin carboxyl extension protein 80,UBA52,UBCEP2,Ubiquitin-60S ribosomal protein L40,CEP52,Ubiquitin A-52 residue ribosomal protein fusion product 1 |
Lieferbar |
|
Background |
Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. |
Buffer |
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
Clonality |
Polyclonal |
Concentration |
1mg/mL |
Dilution |
WB 1:500-1:2000, ELISA 1:20000 |
Immunogen |
Synthesized peptide derived from the human Ub around the acetylation site of K33. |
Purification_Method |
Affinity purification |
Storage |
Store at -20℃. Avoid repeated freeze / thaw cycles. |
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