Alias |
C-C motif chemokine 11,CCL 11,CCL11,CCL11,chemokine (C-C motif) ligand 11,Chemokine C C motif ligand 11,Chemokine CC Motif Ligand 11,Chemokine ligand 11,Eosinophil chemotactic protein,Eotaxin,eotaxin-1,MGC22554,SCYA 11,SCYA11,Small inducible cytokine A11,Small inducible cytokine subfamily A (Cys Cys) member 11,small inducible cytokine subfamily A (Cys-Cys),member 11 (eotaxin),Small inducible cytokine subfamily A member 11,Small-inducible cytokine A11 |
Background |
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. |