Alias |
Actin related protein 1,Actin RPV,Actin-RPV,ACTR 1A,Actr1a,ACTZ,Alpha centractin,Alpha-centractin,ARP 1,ARP1 actin related protein 1 homolog A,ARP1 actin related protein 1 homolog A centractin alpha,ARP1,ARP1 yeast homolog A,Centractin alpha,Centractin,Centrosome associated actin homolog,Centrosome-associated actin homolog,CTRN 1,CTRN1,FLJ52695,FLJ52800,FLJ55002 |
Background |
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. |