Alias |
CD 4,CD4 (L3T4),CD4,CD4 antigen (p55),CD4 antigen,CD4 molecule,CD4 receptor,CD4+ Lymphocyte deficiency,included,CD4,CD4mut,L3T4,Leu3,Ly-4,Lymphocyte antigen CD4,MGC165891,OTTHUMP00000238897,p55,T cell antigen T4,T cell antigen T4/LEU3,T cell differentiation antigen L3T4,T cell OKT4 deficiency,included,T cell surface antigen T4/Leu 3,T cell surface antigen T4/Leu3,T cell surface glycoprotein CD4,T-cell surface antigen T4/Leu-3,T-cell surface glycoprotein CD4,W3/25,W3/25 antigen |
Background |
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |