Alias |
CCYC,Cell cycle checkpoint protein,Cell cycle checkpoint protein RAD17,FLJ41520,HRAD 17,hRad17,R24L,Rad 17,Rad 24,RAD1 (S. pombe) homolog,RAD1 homolog,RAD17,RAD17 homolog (S. pombe),RAD17 homolog,Rad17 like protein,RAD17,S. pombe,homolog of,RAD17,RAD17Sp,Rad24,Rad24,mouse,homolog of,Rad24,S. cerevisiae,homolog of,RF C activator 1 homolog,RF C/activator 1 homolog,RF-C/activator 1 homolog |
Background |
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. |