Alias |
Alternative,short form NMT S,EC 2.3.1.97,Glycylpeptide N tetradecanoyltransferase 1,Glycylpeptide N-tetradecanoyltransferase 1,Long form,NMT L,Myristoyl CoA:protein N myristoyltransferase 1,Myristoyl-CoA:protein N-myristoyltransferase 1,N myristoyltransferase 1,NMT 1,NMT,nmt1,NMT1,Peptide N myristoyltransferase 1,Peptide N-myristoyltransferase 1,Type I N myristoyltransferase,Type I N-myristoyltransferase |
Background |
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein). |