Alias |
C C motif chemokine ligand 23,C-C motif chemokine 23,C6 beta chemokine,CCL 23,CCL23(30-99),CCL23,Chemokine (C C motif) ligand 23,Chemokine CC motif ligand 23,ck beta 8,CK-beta-8,CKB 8,CKB-8,Ckb-8-1,CKB8,Hmrp-2a,Macrophage inflammatory protein 3,MIP 3,MIP-3,MIP3,MPIF 1,MPIF-1,MPIF1,Myeloid progenitor inhibitory factor 1,OTTHUMP00000163948,SCYA 23,SCYA23,Small inducible cytokine A 23,Small inducible cytokine subfamily A (Cys-Cys),Small inducible cytokine subfamily A,member 23,Small-inducible cytokine A23 |
Background |
This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. |