Alias |
BGLAP,BGP,Bone gamma carboxyglutamate (gla) protein,Bone gamma carboxyglutamate gla protein osteocalcin,Bone gamma carboxyglutamate protein,Bone Gla protein,Gamma carboxyglutamic acid containing protein,Gamma-carboxyglutamic acid-containing protein,OC,OCN,OSTCN,Osteocalcin,OTTHUMP00000016586,PMF1 |
Background |
Bone gamma-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. |