Alias |
A kinase (PRKA) anchor protein (gravin) 12,A kinase Anchor Protein 12,A kinase anchor protein 250kDa,A-kinase anchor protein 12,A-kinase anchor protein 250 kDa,AKA12,AKAP 12,AKAP 250,AKAP-12,Akap12,AKAP250,DKFZp686M0430,DKFZp686O0331,FLJ20945,FLJ97621,Gercelin,Gravin,Kinase scaffold protein gravin,Myasthenia gravis autoantigen,Myasthenia gravis autoantigen gravin,OTTHUMP00000017426,OTTHUMP00000017427,Src-Suppressed C Kinase Substrate,Srcs5,SSeCKS,Tsga12 |
Background |
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |