Alias |
Delta sleep-inducing peptide immunoreactor,DIP,DSIP immunoreactive leucine zipper protein,DSIP-immunoreactive peptide,Dsip1,Dsipi,GILZ,Glucocorticoid-induced leucine zipper protein,hDIP,Protein DIP,T22D3,TSC-22-like protein,TSC-22-related protein,TSC-22R,TSC22 domain family protein 3,TSC22 domain family,member 3,TSC22 related inducible leucine zipper 3,TSC22D3 |
Background |
The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene. |