Alias |
Accessory protein like,Accessory protein-like,AcPL,CD218 antigen-like family member B,CD218b,CDw218b,I18RA,IL 18RAcP,IL 1R accessory protein like,IL 1R7,IL 1RAcPL,IL-18 receptor accessory protein,IL-18R-beta,IL-18RAcP,IL-18Rbeta,IL-1R accessory protein-like,IL-1R-7,IL-1R7,IL-1RAcPL,IL18RAP,IL18Rbeta,Interleukin 18 receptor accessory protein,Interleukin-1 receptor 7,Interleukin-18 receptor accessory protein,Interleukin-18 receptor accessory protein-like,Interleukin-18 receptor beta,Interleukin-18 receptor beta chain |
Background |
Interleukin 18 receptor accessory protein, also known asIL18RAPandCDw218b(cluster of differentiationw218b), is a humangene. The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-κB and MAPK8 (JNK) in response to IL18. |