Alias |
AT like disease,Ataxia telangiectasia disorder like,ATLD,DNA recombination and repair protein,Double strand break repair protein MRE11A,Double-strand break repair protein MRE11A,endo/exonuclease Mre11,HNGS1,meiotic recombination (S. cerevisiae) 11 homolog A,Meiotic recombination 11 homolog 1,meiotic recombination 11 homolog A (S. cerevisiae),Meiotic recombination 11 homolog A,MmMRE11A,Mre 11,MRE 11a,MRE 11b,MRE11 homolog 1,MRE11 homolog A,MRE11 homolog double strand break repair nuclease,MRE11 meiotic recombination 11 homolog A (S. cerevisiae),MRE11 meiotic recombination 11 homolog A,MRE11,MRE11A,MRE11b,OTTHUMP00000236830,OTTHUMP00000236831,OTTHUMP00000236832,OTTHUMP00000236833 |
Background |
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |