Alias |
Deoxyribonuclease gamma,Deoxyribonuclease I like 3,Deoxyribonuclease I like III,Deoxyribonuclease I-like 3,DHP 2,DHP2,DNAS1L3,DNase gamma,DNase I homolog protein 2,DNase I homolog protein DHP2,DNase I like 3,DNase I-like 3,DNASE1L3,DNSL3,Liver and spleen DNase,LS DNase,LS-DNase,LSD,SLEB 16,SLEB16 |
Background |
This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |