Alias |
41 kDa ubiquitin specific protease,41 kDa ubiquitin-specific protease,Deubiquitinating enzyme 2,Ubiquitin carboxyl terminal hydrolase 2,Ubiquitin carboxyl-terminal hydrolase 2,ubiquitin specific peptidase 2,Ubiquitin specific processing protease 2,Ubiquitin specific protease 12,Ubiquitin specific protease 9,Ubiquitin specific protease,41kD,Ubiquitin thioesterase 2,Ubiquitin thiolesterase 2,Ubiquitin-specific-processing protease 2,Ubiquitin-specific-processing protease testis,UBP-t,UBP2,UBP41,USP2,USP9 |
Background |
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |