Alias |
FGL 1,Fgl1,FGL1,Fibrinogen like 1,Fibrinogen like protein 1,Fibrinogen related protein 1,Fibrinogen-like protein 1,Hepassocin,Hepatocellular carcinoma related sequence,Hepatocyte derived fibrinogen related protein 1,Hepatocyte-derived fibrinogen-related protein 1,HFREP 1,HFREP-1,HFREP1,HP 041,HP-041,HP041,LFIRE 1,LFIRE-1,LFIRE1,Liver fibrinogen related protein 1,Liver fibrinogen-related protein 1,MFIRE 1,MGC108569,MGC12455,MGC37822,OTTHUMP00000122468 |
Background |
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. |