Alias |
Antigen identified by monoclonal BB2,BB 2,BB2,CD 54,CD_antigen=CD54,CD54,Cell surface glycoprotein P3.58,Human rhinovirus receptor,ICAM 1,ICAM-1,ICAM1,ICAM1,intercellular adhesion molecule 1 (CD54),human rhinovirus receptor,Intercellular adhesion molecule 1,Major group rhinovirus receptor,MALA 2,MALA2,MyD 10,MyD10,P3.58,Surface antigen of activated B cells,BB2 |
Background |
ICAM-1 (intercellular adhesion molecule-1) is a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. ICAM-1 is expressed mainly on monocytes and endothelial cells, but expression can be induced or upregulated on many cell types including B and T lymphocytes. Diseases associated with ICAM1 include Malaria and Leukostasis. Among its related pathways are Immune response CCR3 signaling in eosinophils and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. |