Anti-VDAC1/Porin Mouse mAb

Loading Control Antibodies

Store at -20°C. Avoid freeze/thaw cycles.

Anti-VDAC1/Porin Mouse mAb

PBS, Glycerol, BSA

Recombinant Monoclonal

Voltage-dependent anion channel (VDAC), ubiquitously expressed and located in the outer mitochondrial membrane, is the primary mean by which metabolites diffuse in and out of the mitochondria. In addition, this channel plays a role in apoptotic signaling. The change in mitochondrial permeability characteristic of apoptosis is mediated by Bcl-2 family proteins, which bind to VDAC, altering the channel kinetics. Homodimerization of VDAC may be a mechanism for changing mitochondrial permeability and supporting release of cytochrome c. In mammalian cells, there are three VDAC isoforms, VDAC1, which is the most widely expressed isoform, as well as VDAC2 and VDAC3.