Anti-FKBP52 Rabbit mAb

Uncategorized

Store at -20°C. Avoid freeze/thaw cycles.

Anti-FKBP52 Rabbit mAb

PBS, Glycerol, BSA

Recombinant Monoclonal

FKBP52, also known as Peptidyl-prolyl cis-trans isomerase FKBP4, is a protein that is encoded by the FKBP4 gene in human. FKBP52 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. It is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, FKBP52 does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.