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Anti-p21 Rabbit mAb

ArtNr PTM-6510
Hersteller PTM Biolabs
Menge 100 ul
Kategorie
Typ Antibody Monoclonal
Format Lyophilized powder
Applikationen WB, IP, IHC-P
Clon JRMR-10499(2)-22
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias MDA-6, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Type
Primary Antibodies
Manufacturer - Category
Uncategorized
Manufacturer - Targets
p21
Storage Conditions
Store at -20°C. Avoid freeze/thaw cycles.
Manufacturer - Research Area
Cell Biology, Epigenetics , Cancer, Signal Transduction
Product description
Anti-p21 Rabbit mAb
Purification Method
Protein A purified
Constituents
PBS, Glycerol, BSA
PTM
Unmodified
Clonality
Recombinant Monoclonal
Stability
Stable for 12 months from date of receipt/reconstitution.
Background
This protein is a potent cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus as a regulator of cell cycle progression at G1. The expression of this protein is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation.
Cellular Localization
Nucleus

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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