Anti-KLF4 Rabbit mAb

Uncategorized

Store at -20°C. Avoid freeze/thaw cycles.

Anti-KLF4 Rabbit mAb (Clone JRMR-10010-21H1L1)

PBS, Glycerol, BSA

Recombinant Monoclonal

KLF4 belongs to the kruppel transcription factor family, which binds to the 5'-CACCC-3' core sequence, acting as both an activator and an inhibitor. KLF4 binds to the promoter region of its own genes and can activate its own transcription. KLF4 regulates the expression of key transcription factors during embryonic development and regulates the maintenance and differentiation of embryonic stem cells; KLF4 contributes to the down- regulation of p53/TP53 transcription and is a key regulator of normal cell proliferation. It can inhibit the proliferation of neuroblastoma, pancreatic cancer, colorectal cancer, hepatocellular carcinoma, et al. For example, in human pancreatic cancer, KLF4 reduces tumor cell proliferation by inducing the CDK inhibitors CDKN1A and CDKN1B (encoding p27; also known as KIP1) and reducing the expression of cyclin D1 (CCND1) and FOXM1.