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Anti-Acetyl-Histone H3 (Lys122) Rabbit pAb

ArtNr PTM-184
Hersteller PTM Biolabs
Menge 100 ul
Kategorie
Typ Antibody Polyclonal
Format Lyophilized powder
Applikationen WB
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Konjugat/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias H3K122ac
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Type
Primary Antibodies
Manufacturer - Category
Histone & Histone Modification Antibodies
Manufacturer - Targets
Histone H3
Storage Conditions
Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight
15
Manufacturer - Research Area
Epigenetics
Product description
Anti-Acetyl-Histone H3 (Lys122) Rabbit pAb
Purification Method
Protein A and immunogen affinity purified
Constituents
PBS, Glycerol, BSA
PTM
Acetyl
Modification Site
Lys122
Clonality
Polyclonal
Stability
Stable for 12 months from date of receipt/reconstitution.
Background
The ε-amino lysine acetylation of proteins is an important reversible modification controlling protein activity. The amino-terminal tails of core histones undergo lysine acetylation in multiple sites, termed as “histone code”. Lysine acetylation in core histones occurs in response to various stimuli and plays vital roles in the regulation of many cellular processes including chromatin dynamics, DNA transcription, cell cycle progression, apoptosis, differentiation, and nuclear import. In most species, histone H2A is primarily acetylated at Lys5, 9, 15, and 36; H2B is primarily acetylated at Lys5, 12, 15, 16, and 20. Histone H3 is primarily acetylated at Lys4, 9, 14, 18, 23, 27, 56, and 79. Histone H4 is primarily acetylated at Lys5, 8, 12, 16, and 20. More than 20 histone acetyltransferases (HATs) and 18 histone deacetylases (HDACs) have been identified to date, while the mechanistic details of substrate selection and site specificity of these enzymes remain unclear. The regulation of histone lysine acetylation status is impaired in the pathologies of cancer and other diseases and therefore, enzymes regulating histone lysine acetylation have become promising targets for anti-cancer drugs.
Cellular Localization
Nucleus

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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