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HOOK3 Antibody

HOOK3 Antibody

ArtNr	PRS-8425-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Thyroid Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	hook microtubule-tethering protein 3, HK3, h-hook3, hHK3, FLJ31058, Protein Hook homolog 3
Lieferbar
Shipping	blue ice or RT
By Research Area	Homeostasis
Immunogen	HOOK3 antibody was raised against a 19 amino acid peptide from near the amino terminus of human HOOK3. The immunogen is located within amino acids 210 - 260 of HOOK3.
Applications	HOOK3 antibody can be used for the detection of HOOK3 by Western blot at 1 - 2 μ g/mL. Antibody can also be used for immunohistochemistry at 10 μ g/ml. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity	HOOK3 antibody is human, mouse and rat reactive. HOOK3 antibody is predicted to not cross-react with HOOK1 and HOOK2.
Positive Control 1	Cat. No. 1463 - Rat Brain Tissue Lysate
Predicted Molecular Weight	Predicted: 79 kDa Observed: 77 kDa
Purification	HOOK3 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	HOOK3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	HOOK3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Related Products	Cat. No. 8425P – HOOK3 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	HOOK3
Accession #	NP_115786
Protein Gi #	14165274
Ncbi Gene Id #	84376
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	HOOK3
Ncbi Official Full Name	Hook microtubule-tethering protein 3
Ncbi Organism	homo sapiens
Swissprot #	Q86VS8
Background	The HOOK proteins (HOOK1, HOOK2 and HOOK3) comprise a family of cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules mediating the spatial organization of diverse membrane-trafficking systems; their more divergent C-terminal domains mediate binding to organelles (1, 2). HOOK3 exists as a homodimer and participates in defining the architecture and localization of the Golgi complex through its central coiled-coil domain (3). HOOK3 may regulate clearance of endocytosed receptors such as MSR1 (3, 4).
Background References 1	Walenta JH, Didier AJ, Liu X, et al. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J. Cell Biol. 2001; 152:923-34.
Background References 2	Sano H, Ishino M, Krämer H, et al. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. J. Biol. Chem. 2007; 282:7973-81.
Background References 3	Herrmann L, Wiegmann C, Arsalan-Werner A, et al. Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PLoS One 2015; 10:e0119423.
Background References 4	Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocr. Relat. Cancer 2007; 14:445-52.
1st Image Caption	Western blot analysis of HOOK3 in mouse brain tissue lysate with HOOK3 antibody at 1 μ g/ml.
2nd Image Caption	Immunohistochemistry of HOOK3 in mouse brain tissue with HOOK3 antibody at 10 μ g/ml.
3rd Image Caption	Immunofluorescence of HOOK3 in mouse brain tissue with HOOK3 antibody at 20 μ g/ml. Red: HOOK3 Antibody (8425) Blue: DAPI staining

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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