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CDO1 Antibody

CDO1 Antibody

ArtNr	PRS-8137-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Kategorie	Antibodies Western Blot ELISA Primary Antibodies
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cysteine dioxygenase type I, CDO, CDO-I, Cysteine dioxygenase type 1
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Shipping	blue ice or RT
By Research Area	Homeostasis
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (84%)
Immunogen	CDO1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CDO1. The immunogen is located within amino acids 30 - 80 of CDO1.
Applications	CDO1 antibody can be used for detection of CDO1 by Western blot at 1 - 2 μ g/ml. Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Specificity	CDO1 antibody is human, mouse and rat reactive.
Positive Control 1	Cat. No. 1464 - Rat Liver Tissue Lysate
Predicted Molecular Weight	Predicted: 22 kDa Observed: 24 kDa
Purification	CDO1 antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	CDO1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	CDO1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Related Products	Cat. No. 8137P – CDO1 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	CDO1
Accession #	NP_001792
Protein Gi #	56786147
Ncbi Gene Id #	1036
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	CDO1
Ncbi Official Full Name	Cysteine dioxygenase type 1
Ncbi Organism	homo sapiens
Swissprot #	Q16878
Background	CDO1 (cysteine dioxygenase, type I) belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis (1). CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine (1, 2). CDO1 exists as a monomer and is expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart (1). CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell (3, 4).
Background References 1	McCann KP, Akbari MT, Williams AC, et al. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. Biochim. Biophys. Acta 1994; 1209:107-10.
Background References 2	Ye S, Wu X, Wei L, et al. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. J. Biol. Chem. 2007; 282:3391-402.
Background References 3	Booken N, Gratchev A, Utikal J, et al. Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. Leukemia 2008; 22:393-9.
Background References 4	Wrangle J, Machida EO, Danilova L, et al. Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer. Clin. Cancer Res. 2014; 20:1856-64.
1st Image Caption	Western blot analysis of CDO1 in rat liver tissue lysate with CDO1 antibody at (A) 1 and (B) 2 μ g/ml.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 0.02 mg

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