MAP2K3 (phospho Thr222) Antibody

Phospho-Specific

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

39 kDa

Polyclonal

Unconjugated

1 mg/mL

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

MAP2K3

24638466

MAP2K3

Homo sapiens

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells.

Moriguchi T., J. Biol. Chem. 271:26981-26988(1996).

Western blot analysis of extracts from Jurkat cells treated with serum using MAP2K3 (Phospho-Thr222) Antibody. The lane on the right is treated with the antigen-specific peptide.