ArtNr |
PRS-79-393-0.1mg |
Hersteller |
ProSci
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Liquid |
Applikationen |
WB, IF, IHC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
P62DOK, CK2A1, DOK1 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Other |
Immunogen |
p62Dok (Ab-398) antibody was raised against a peptide sequence around aa.396~400 (P-I-Y-D-E) derived from Human p62Dok. |
Applications |
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200 |
Specificity |
This antibody detects endogenous level of total p62Dok protein. |
Predicted Molecular Weight |
62 kDa |
Purification |
Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Clonality |
Polyclonal |
Conjugate |
Unconjugated |
Buffer |
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Concentration |
1 mg/mL |
Storage Conditions |
Store antibody at -20˚ C for up to one year. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
DOK1 |
Accession # |
NP_001372.1 |
Protein Gi # |
4503357 |
Ncbi Gene Id # |
1796 |
Ncbi Official Symbol |
DOK1 |
Ncbi Official Full Name |
docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q99704 |
Background |
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
Background References 1 |
Michael J. Wick, et, al. (2001) J. Biol. Chem; 276: 42843 - 42850. Paul D. Simoncic, et, al. (2006) Mol. Cell. Biol; 26: 4149 - 4160. Nadia Dube, et, al. (2004) PNAS; 101: 1834. Adam C. Yopp, et al. (2005) J. Immunol; 175: 2913 - 2924. |
1st Image Caption |
Western blot analysis of lysed extracts from K562, HL-60 and JK cells using p62Dok (Ab-398). |
2nd Image Caption |
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p62Dok (Ab-398).Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells using p62Dok (Ab-398). |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.