OASL Antibody

Homeostasis

OASL antibody can be used for detection of OASL by Western blot at 1 - 2 μ g/ml. Antibody can also be used for Immunocytochemistry at 2.5 μ g/mL. For Immunoflorescence start at 20 μ g/mL.

Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Cat. No. 1410 - Mouse Bladder Tissue Lysate

Predicted: 57 kDa

Observed: 65 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 7775P – OASL Peptide

None

NP_003724

8638

OASL

homo sapiens

OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).

Hartmann R, Olsen HS, Widder S, et al. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Nucleic Acids Res. 1998; 26:4121-8.

Andersen JB, Strandbygård DJ, Hartmann R, et al. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. Eur. J. Biochem. 2004; 271:628-36.

Immunocytochemistry of OASL1 in HepG2 cells with OASL1 antibody at 2.5 μ g/mL.